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KMID : 1134820110400050665
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Journal of the Korean Society of Food Science and Nutrition
2011 Volume.40 No. 5 p.665 ~ p.672
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Effects of Organic Ca Supplements on Ca Bioavailability and Physiological Functions in Ovariectomized Osteoporotic Model Rats
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Cho Su-Jung
Park Mi-Na
Kim Hee-kyong
Kim Jae-hong
Kim Min-ho
Kim Wan-Sik
Lee Yeon-Sook
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Abstract
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We evaluated the effects of organic Ca supplements chelated with milk protein (CaMP) in ovariectomized osteoporotic rats. Eight week-old Sprague-Dawley female rats were ovariectomized and fed a low CaCO₃ diet (0.1%) for 4 weeks to create an osteoporotic model. At that point, L4-CaCO₃ rats were sacrificed and the rest of the rats were divided into 4 groups, each of which was fed an experimental diet for 4 weeks: low-CaCO₃ (0.1%; L8-CaCO₃) and CaMP at 3 Ca levels: low (0.1%; L8-CaMP), normal (0.5%; N8-CaMP), and high (1.5%; H8-CaMP). Daily weight gain, serum ALP, weight and breaking force of femurs, Ca content of the lumbar, and Ca absorption were measured. Daily weight gain increased in the N8-CaMP and H8-CaMP groups compared to the low Ca groups. The ALP activity in the CaMP-fed rats was significantly lower than in the CaCO₃-fed rats. Both breaking force and femur weight were higher in the N8-CaMP and H8-CaMP groups compared to the L8-CaCO₃ group. Ca content of the lumbar increased dose-dependently with Ca intake levels of CaMP. Ca absorption rates of the CaMP-fed rats increased more than that of the rats fed low Ca levels of CaCO₃. These results demonstrate that the CaMP supplement had positive effects on bone metabolism and Ca bioavailability in ovariectomized osteoporotic rats. Therefore, CaMP may be recommended as a useful Ca supplement to prevent bone loss in osteoporosis.
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KEYWORD
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organic Ca supplement, milk protein, bioavailability, physiological function, osteoporosis
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